人体尿液的代谢分析与毒素暴露有关
Nuria Dasí-Navarro1, Sonia Lombardi2, Pilar Vila-Donat1
1Biotech Agrifood, Faculty of Pharmacy and Food Sciences, University of Valencia, 46100 Burjassot, Spain.
Toxins
|February 25, 2025
概括
妇女接触菌毒素会改变脂肪酸代谢,影响不和脂肪酸生物合成. 这项研究使用代谢学来揭示菌毒素的毒理途径和健康影响.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 毒理学 毒理学 毒理学
背景情况:
- 菌毒素由于致癌性和神经毒性作用,造成全球健康风险.
- 了解真菌毒素的毒理机制对于公共卫生至关重要.
- 人类暴露于菌毒素,如恩尼亚和亚毒素是一个重大问题.
研究的目的:
- 通过尿液代谢物分析,研究受菌毒素暴露影响的代谢途径.
- 为了确定特定的代谢物和途径改变了菌毒素在女性队列.
- 提高对菌毒素对健康的影响和毒性机制的理解.
主要方法:
- 分析了西班牙INMA队列中的540名妇女的尿液样本.
- 稀释和射击提取,然后通过HPLC-Q-TOF-MS进行代谢物识别.
- 使用Agilent软件和METLIN数据库进行路径分析的数据处理.
主要成果:
- 每个样本确定了2000多种代谢物.
- 不和脂肪酸的生物合成是受影响最明显的途径 (调整后的p值=0.007).
- 主要受影响的代谢物包括酸,酸,酸代谢物和油酸.
结论:
- 代谢学对于阐明菌毒素毒性机制至关重要.
- 毒素暴露显著影响脂肪酸代谢和相关途径.
- 这项研究提供了关于真菌毒素对健康的影响的见解,特别是新兴的真菌毒素.
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