创新的真菌毒素排毒剂降低了阿弗拉托克辛B1的吸收率,并抵消了暴露于食物中低水平真菌毒素的肉中氧化应激
Matteo Cuccato1, Neenu Amminikutty1, Veronica Spalenza1
1Department of Veterinary Sciences, University of Torino, 10095 Grugliasco, Italy.
Toxins
|February 25, 2025
概括
两种新的真菌毒素排毒剂 (MyDA) 有效地降低了 brojlers.aflatoxin B1 (AFB1) 的吸收. 这些药物减轻了AFB1诱导的氧化应激,并逆转了负面的基因表达变化,显示了家禽健康的前景.
科学领域:
- 动物科学动物科学
- 毒理学 毒理学 毒理学
- 料添加剂 料添加剂
背景情况:
- 非洲毒素B1 (AFB1) 通过破坏生长和降低肉和蛋的质量,导致家禽的经济损失很大.
- 菌毒素排毒剂 (MyDA) 可以在胃肠道中结合AFB1,减少其吸收并减轻不良影响.
研究的目的:
- 评估两种创新的MyDA,SeOX和CHS在降低AFB1生物可访问性和减轻其在 brojlers中的毒性影响方面的有效性.
- 评估MyDA对AFB1水平,氧化应激标志物和肉基因表达的影响.
主要方法:
- 肉暴露于AFB1 (0.02毫克/公斤) 10天,有或没有SeOX或CHS治疗.
- 测量了AFB1分泌,血清抗氧化能力,肝脂过氧化,抗氧化酶活性,谷氨水平和基因表达 (CYP2A6,Nrf2).
主要成果:
- 无论是SeOX还是CHS都显著降低了AFB1的生物可访问性近30%.
- MyDA治疗显著减轻了AFB1诱导的氧化应激,通过提高抗氧化能力和减少脂质过氧化来证明.
- 由AFB1诱导的CYP2A6上调和Nrf2下调被SeOX和CHS扭转.
结论:
- 创新的MyDA,SeOX和CHS,有效地限制了 brojlers中的AFB1吸收.
- 这些药物成功地减轻了AFB1诱导的氧化应激,并调节了相关的基因表达,为管理家禽料中的真菌毒素污染提供了可行的解决方案.
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