相关实验视频
Updated: May 7, 2026

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.1K
甲状腺内在时钟的破坏加剧了实验性自身免疫甲状腺炎
Journal of molecular endocrinology
|February 25, 2025
概括
核心时钟基因Bmal1调节甲状腺时钟,并影响自身免疫性甲状腺炎的严重程度. 在甲状腺细胞中击败Bmal1会通过增加抗体和炎症而使自身免疫性甲状腺炎恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 核心时钟基因Bmal1与炎症和自身免疫性疾病有关.
- 以前的研究表明,光线的变化会破坏甲状腺时钟,并使自身免疫性甲状腺炎 (AIT) 恶化.
研究的目的:
- 研究甲状腺钟在自身免疫性甲状腺炎 (AIT) 中的特定作用.
- 研究甲状腺细胞中Bmal1对AIT发育和严重性的影响.
主要方法:
- 使用甲状腺细胞特异性Bmal1敲除 (cKO) 鼠标模型.
- 在不同的免疫时间点下,在cKO和对照小鼠中比较实验性自身免疫甲状腺炎 (EAT) 严重程度.
- 测量了抗铁血球蛋白抗体 (TgAb),炎症细胞因子和CD4+ T细胞反应.
主要成果:
- 甲状腺细胞中的Bmal1敲击破坏了甲状腺内钟基因节律.
- 当在ZT6免疫时,cKO和对照小鼠都显示出更严重的EAT,而不是ZT18.
- 与对照组相比,cKO-EAT小鼠的TgAb水平较高,炎症性细胞因子增加,CD4+ T细胞反应增强.
结论:
- Bmal1在调节甲状腺时钟方面发挥着新的作用.
- 甲状腺Bmal1调节了实验性自身免疫甲状腺炎 (EAT) 的严重程度.
- 循环节律调节是甲状腺自身免疫性疾病中以前未被识别的因素.
相关概念视频
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Autoimmune Disorders
378
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
378

