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通过环应变调节设计小型有机分子NIR-II光体

Xingyu Wang¹, Tuanwei Li¹, Xiaohu Yang¹

¹CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. twli2020@sinano.ac.cn.

Chemical communications (Cambridge, England)

|February 25, 2025

概括

研究人员开发了新的有机光体,用于体内生物成像. 通过调整基于桑的分子中的环应变,他们调整了光学特性,在第二次近红外窗口 (NIR-II) 中提高了性能.

科学领域:

有机化学有机化学
材料科学材料科学材料科学
生物医学成像技术生物医学成像技术

背景情况:

开发用于第二次近红外窗口 (NIR-II,1000-1700nm) 的有机光体对于先进的体内生物成像和生物感应至关重要.
现有的光体通常需要优化,以获得卓越的光物理性质和体内适用性.

研究的目的:

探索一种用于调节基于香的光体光学特性的新策略.
为了研究由环大小控制的环应变对光体特征的影响.
为生物传感应用开发响应性光体.

主要方法:

合成了一系列基于桑的光体,其环形大小有系统的变化.
研究了环大小,环应变,分子刚性和平面性之间的关系.
分析了合成化合物的光物理性质 (吸收,排放,量子产量).
通过测量受螺旋环化影响的pK_cycl值来评估光体的响应性.

主要成果:

微调色衍生物的环形大小有效调节了它们的环形应变.
增加的环应变导致结合系统的刚性和平面性增强,显著影响光学性能.
由于环应变的螺旋循环化影响了pK_cycl值,从而赋予了对光体的反应性.
开发的光体显示出在NIR-II窗口中的应用潜力.

结论:

通过控制的环大小来操纵环应变是一种可行的策略,可以调整基于ksanthene的光体的光学特性.
这种方法使得在NIR-II地区能够开发出具有可取特征的新型有机光体,用于体内生物成像和生物传感.
这项研究为设计下一代响应式光探针提供了基础.

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