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Updated: May 8, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
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时间解决的多蛋白质组分析使得在Jurkat T细胞激活过程中N-甘化模式变化的系统表征成为可能

Mingming Dong1, Xiaoyan Liu2,3, Changrui Zhao4

  • 1MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, 116000, Liaoning, China. dongmm@dlut.edu.cn.

Analytical and bioanalytical chemistry
|February 25, 2025
PubMed
概括

这项研究揭示了T细胞激活期间蛋白质糖化中的动态变化,确定了关键的糖和涉及的酶. 这些发现为免疫反应调节提供了新的治疗点.

关键词:
葡萄糖酶化模式是如何形成的完好无损的葡萄糖.多种蛋白质组分析在T细胞激活过程中,

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相关概念视频

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...