机械功率与COVID-19机械通风患者的死亡率无关
Enric Barbeta1,2,3, Cláudia Barreiros2, Edoardo Forin4
1CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Annals of intensive care
|February 25, 2025
概括
机械功率组件最初没有预测COVID-19患者的死亡率. 然而,在三天后,静态弹性强度和总弹性强度与死亡率的增加有关,类似于正极呼气压.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统生理学 呼吸系统生理学
- 机械通风机械通风机械通风
背景情况:
- 机械动力组件在死亡率中的作用受到辩论.
- 之前没有任何研究研究了COVID-19患者的机械功率.
研究的目的:
- 评估总和组件机械功率对COVID-19急性呼吸衰竭死亡率的影响.
- 分析侵入性通风患者机械功率与90天死亡率之间的关联.
主要方法:
- 对CIBERESUCICOVID多中心观察队列研究的二次分析.
- 包括799名COVID-19急性呼吸衰竭患者,接受入侵性机械通风 (MV).
- 检查了机械功率组件和90天死亡率之间的关联,调整了混因素.
主要成果:
- 最初的机械功率和组件显示与90天死亡率没有关联.
- 三天后,总弹性和静态弹性强度与更高的90天死亡率有关.
- 阳性末端呼气压也显示出与死亡率的类似关联.
结论:
- 机械功率及其组件并不是COVID-19中MV启动时死亡率的独立预测因素.
- 三天后,静态弹性和总弹性功率与死亡风险增加相关.
- 阳性呼吸末端压力和平原压力同样反映了这种风险.
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