胰岛素抵抗和估计的第一个硬心血管事件的10年风险
Zhen Yang1,2,3, Jun-He Shi1, Shan He4
1China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing, 100091, China.
Current medical science
|February 25, 2025
概括
通过QUICKI测量的胰岛素抵抗增加与患心血管疾病的风险更高有关. 这一发现强调了新陈代谢健康在预防心脏事件中的重要性.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 胰岛素抵抗是主要的代谢功能障碍.
- 心血管疾病仍然是全球死亡的主要原因.
- 了解胰岛素抵抗和心血管事件之间的联系对于预防策略至关重要.
研究的目的:
- 调查胰岛素抵抗与动脉样硬化心血管事件的10年风险之间的联系.
- 使用定量胰岛素敏感性检查指数 (QUICKI) 和稳态模型评估β细胞功能 (HOMA-β) 来衡量胰岛素抵抗.
主要方法:
- 使用国家健康和营养检查调查数据 (1999-2018) 的横截面研究,共有2128名参与者 (年龄在40-79岁之间).
- 多变量线性回归和平滑曲线拟合分析了QUICKI,HOMA-β和10年心血管事件风险之间的关联.
- 调整为多个混因素,包括年龄,BMI,血压,吸烟和糖尿病.
主要成果:
- 较低的QUICKI得分 (表明更高的胰岛素抵抗) 与增加动脉样硬化心血管事件的10年风险显著相关 (β = -8.85,CI [-15.77,-1.93]).
- 更高的HOMA-β值也与10年心血管风险增加有关 (β = 6.84,CI [0.45,13.23]).
- 性别特定的分析证实了QUICKI与男性和女性心血管风险的关联.
结论:
- 增加胰岛素抵抗是心血管疾病的重要危险因素.
- 快速和HOMA-β是评估与胰岛素抵抗有关的心血管风险的有价值指标.
- 这些发现强调了控制胰岛素抵抗对心血管健康的重要性.
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