肝细胞癌患者免疫治疗的完整反应
Mir Lim1, Magdalena Espinoza2, Yi-Hsiang Huang3
1Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
JAMA network open
|February 25, 2025
概括
肝细胞癌患者在免疫疗法获得完整反应后,表现为持久的生存和罕见的复发. 像PD-L1表达和瘤DNA水平这样的生物标志物可以预测这些结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 肝细胞癌研究 肝细胞癌研究
背景情况:
- 免疫疗法是肝细胞癌 (HCC) 的首要治疗方法,但完全反应率很低.
- 在HCC中完全响应的长期意义和预测因素仍然不清楚.
研究的目的:
- 评估免疫疗法完全响应的HCC患者的长期生存结果.
- 确定与实现完整反应相关的临床和基因组因素.
主要方法:
- 对IMbrave150试验的后期分析和对先进的HCC患者进行前线免疫治疗的多中心队列研究.
- 完全响应是根据RECIST 1.1标准定义的.
- 使用卡普兰-梅尔曲线和日志等级测试分析了生存结果.
主要成果:
- 完全响应者表现出高两年无病生存率 (58.0%-87.4%) 和整体生存率 (81.1%-93.3%) 在队列中.
- 在完全响应者中,在停止治疗后疾病复发是罕见的.
- 完全响应者表现出更高的PD-L1蛋白表达和更低的循环瘤DNA水平,但没有独特的遗传改变.
结论:
- 在HCC中,免疫治疗的完整反应与延长生存和持续的疾病控制有关.
- 免疫细胞PD-L1表达和循环瘤DNA水平可能作为预测反应的潜在生物标志物.
- 对这些生物标志物的进一步研究是个性化HCC治疗策略的必要条件.
相关概念视频
Tumor Immunotherapy
462
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
462
Cytotoxic T Cells-mediated Immune Response
826
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
826


