在EPIC中,遵守地中海饮食和与肥胖相关的癌症风险
Inmaculada Aguilera-Buenosvinos1,2, Fernanda Morales Berstein3,4, Esther M González-Gil5
1Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
JAMA network open
|February 25, 2025
概括
对地中海饮食 (MedDiet) 的更高坚持与与肥胖有关的癌症 (ORCs) 的风险降低有关. 这种关联似乎独立于体重指数和腰比,这表明MedDiet的直接保护作用.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 地中海饮食 (MedDiet) 与较低的癌症发病率和减轻体重增加有关.
- 肥胖是各种癌症的重要风险因素,而MedDiet的坚持表明与肥胖有相反的关系.
研究的目的:
- 调查MedDiet的坚持与与肥胖有关的癌症 (ORCs) 的风险之间的关联.
- 探索肥胖在这种关联中的潜在调解作用.
主要方法:
- 使用欧洲癌症和营养前性调查 (EPIC) 研究数据的前性队列研究.
- 坚持MedDiet的得分分为9分;ORC发病率根据国际癌症研究机构的标准进行分类.
- 使用多变量Cox比例危险回归和中介分析.
主要成果:
- 超过45万名参与者接受了平均14.9年的随访.
- 较高的MedDiet坚持 (7-9分) 与较低的坚持 (0-3分) 相比,与ORC风险 (HR,0.94;95% CI,0.90-0.98) 的适度,统计学显著降低有关.
- 调解分析没有支持腰比或体重指数在MedDiet-ORC风险关系中的作用.
结论:
- 增加对MedDiet的坚持与ORC风险的适度降低有关.
- 这种保护性关联似乎独立于脂肪度的测量.
- 需要进一步的研究来阐明MedDiet在癌症预防中的作用背后的精确机制.
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