托布拉米辛的药理动力学在患有初级动脉动力障碍的儿科患者中
Nathaniel J Macatangay1, Samantha Engdahl2, Rebecca S Pettit2
1Children's Hospital, University of Missouri Health Care, Columbia, Missouri, USA.
患有原发性纤维肌动力障碍 (PCD) 和囊性纤维化 (CF) 的儿科患者在治疗肺部恶化时表现出类似的托布拉米辛药理学和临床结果. 剂量和治疗时间在两组之间是可比的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
- 儿科 儿科 儿科
背景情况:
- 肺部恶化的初级状动力障碍 (PCD) 治疗通常涉及静脉注射托布拉米辛.
- 对于托布拉米在患有PCD的儿科患者中的药理动力学数据有限.
- 这项研究旨在将儿科PCD患者的托布拉米辛药理学与囊性纤维化 (CF) 患者的药理学进行比较.
研究的目的:
- 在肺部恶化期间,在PCD和CF的儿科患者之间比较托布拉米辛的药理动力学.
- 为了评估托布拉米辛的消除速率常数和分布体积是否在这两组患者之间有所不同.
- 评估与托布拉米辛治疗相关的临床结果在儿科PCD与CF患者.
主要方法:
- 在2018年1月至2023年6月期间因肺部恶化住院的儿科患者的回顾性研究.
- 纳入标准:用全身托布拉米辛治疗,并至少进行两次可用于药理动力学分析的度测量.
- 患有PCD的患者与基于年龄的CF患者相匹配1:2;主要结局是托布拉米辛消除速率常数.
主要成果:
- 七名PCD患者与14名CF患者匹配;基线特征相似.
- 在托布拉米辛排泄速率常数 (0.510对0.493小时−1,p=0.433) 或分布体积 (0.31对0.23L/kg,p=0.640) 中没有发现显著差异.
- 临床结果,包括急性损伤发病率,托布拉米辛治疗的持续时间和停留时间在各组之间是可比的.
结论:
- 托布拉米辛的药理动力学,特别是消除速率常数,在患有PCD和CF的儿科患者之间没有显著差异.
- 临床结果相似,表明托布拉米辛在两种疾病中的疗效和安全性相似.
- 对于PCD患者的较低托布拉米辛剂量趋势需要进一步调查.
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