在喘患者中使用口服皮质类固醇相关的并发症:回顾性队列研究
Chih-Cheng Lai1,2, Chao-Hsien Chen3,4,5, Ya-Hui Wang6
1Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Expert review of clinical pharmacology
|February 25, 2025
概括
需要口服皮质类固醇 (OCS) 治疗喘的患者面临严重健康问题的风险增加. 这项研究发现,短期和长期的OCS使用对骨质疏松症和糖尿病等疾病的风险显著增加.
科学领域:
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 服用口服皮质类固醇 (OCS) 的喘患者有更高的副作用风险.
- 在坚持指导方针治疗的患者中,OCS不良事件的研究有限.
- 本研究检查了高剂量吸入性皮质类固醇 (ICS) 用户患有失控喘的OCS副作用.
研究的目的:
- 评估口服皮质类固醇 (OCS) 对喘患者的不良影响.
- 评估使用高剂量吸入性皮质类固醇 (ICS) 和需要OCS的患者的风险.
- 为了比较OCS用户和非用户之间的不良事件概况.
主要方法:
- 对173835名来自台湾绩效支付计划的喘患者进行了回顾性队列研究.
- 患者使用高剂量的ICS超过90天.
- 根据短期 (≥450mg/90天) 和长期 (≥900mg/180天) 的OCS使用情况,分类为对照组 (没有OCS) 和OCS组.
主要成果:
- 短期和长期的OCS用户都显示出显著增加不良结果的风险.
- 评估的风险包括骨质疏松症,糖尿病,高血压,感染,心血管疾病,精神健康障碍和眼部疾病.
- 一个庞大的患者队列证实了OCS使用与不良健康事件之间的联系.
结论:
- 口服皮质类固醇 (OCS) 与喘患者的健康风险有关.
- 临床医生应该探索替代策略,以减轻伤害,同时保持喘控制.
- 尽量减少OCS暴露对于改善患者的治疗结果和减少并发症至关重要.
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