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Updated: May 26, 2025

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评估禁食新陈代谢及其与小鼠核心昼夜时钟的关系的协议

Jiameng Sun1, Brian J DeBosch2

  • 1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

STAR protocols
|February 25, 2025
PubMed
概括

这项研究详细介绍了评估小鼠禁食新陈代谢及其与昼夜时钟的联系的协议. 它涵盖实验设置,基质评估和代谢救援策略.

关键词:
遗传学 遗传学 遗传学 是一个代谢 代谢 代谢 代谢模型生物模型生物.

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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