宫和马塞特静脉引起的肌原潜力在2型糖尿病中
Sujeet Kumar Sinha1, Krishnapriya Moothedath Vipinan1
1Center of Excellence for Persons with Tinnitus and Vestibular Disorders, Department of Audiology, All India Institute of Speech and Hearing, Mysore, Karnataka.
American journal of audiology
|February 25, 2025
概括
2型糖尿病显著延长了宫和masseter前庭唤起肌原潜力 (cVEMP和mVEMP) 的延迟时间,并降低了cVEMP的振幅. 这些发现表明,与糖尿病有关的神经和迷宫功能障碍会影响前庭功能.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病会影响多个器官系统,包括外周听力和前庭系统.
- 以前的研究表明,糖尿病患者的宫前庭引起肌原潜力 (cVEMP) 和眼部VEMP (oVEMP) 的变化.
- 马塞特VEMP (mVEMP) 是一种新兴的技术,用于评估前庭细胞质质体反射通路.
研究的目的:
- 在2型糖尿病患者中研究和描述cVEMP和mVEMP的延迟和振幅参数.
- 为了比较患有糖尿病和没有糖尿病的人之间的VEMP反应,以确定潜在的糖尿病相关的前庭功能障碍.
主要方法:
- 该研究包括21名患有2型糖尿病的参与者和21名年龄和性别匹配的对照.
- 记录了cVEMP和mVEMP,使用在125dB peSPL的500Hz音频爆发刺激.
- 分析了延迟 (P11,P13,N21,N23) 和振幅 (cVEMP 的 P13-N23,mVEMP 的 P11-N21) 的参数.
主要成果:
- 与对照组相比,患有糖尿病的参与者表现出明显延长的P13 (cVEMP) 和P11 (mVEMP) 延迟时间 (p = .00).
- 在糖尿病组 (M=0.71) 与对照组 (M=1.44,p = .00) 之间观察到cVEMP振幅 (P13-N23) 的显著降低.
- 两组之间没有发现N23/N21延迟或mVEMP幅度的显著差异,也没有发现糖尿病持续时间和VEMP参数之间的相关性.
结论:
- 糖尿病与延长cVEMP和mVEMP延迟和减少cVEMP振幅有关,这表明神经和迷宫损伤.
- 糖尿病的静脉功能障碍可能有所不同,影响不同的反射通路.
- 尽管有共同的囊原,但cVEMP和mVEMP反应在本研究中没有相关性,这表明不同的途径参与或对糖尿病变化的敏感性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Pathophysiology of Diabetes
842
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
842
Myasthenia Gravis: Diagnostic Tests
600
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
600
Diabetes: Symptoms, Diagnosis, and Complications
495
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
495
Diabetes: Management and Pharmacotherapy
227
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
227


