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作为对MICT和HIIT运动方式的反应,骨肌肉的转录基因适应

Weihao Hong¹, Yisheng Luan¹, Jianrong Zheng²

¹Division of Sports Science and Physical Education, Tsinghua University, Beijing, China.

|February 25, 2025

概括

中等强度持续训练 (MICT) 和高强度间歇训练 (HIIT) 诱导了不同的骨肌肉适应. 在MICT中较高的胰岛素样生长因子1 (IGF-1) 可能通过PI3K-AKT-FoxO和MAPK通路驱动这些差异.

科学领域:

运动生理学运动生理学
分子生物学分子生物学
骨肌肉的可塑性骨肌肉的可塑性

背景情况:

运动诱导了显著的骨肌肉适应.
中等强度持续训练 (MICT) 和高强度间歇训练 (HIIT) 引起不同的反应.
这些独特适应的基础上的分子机制尚未完全理解.

研究的目的:

在小鼠骨肌中调查MICT和HIIT之间的转录组差异.
确定关键的分子通路和参与运动诱导肌肉适应的基因.

主要方法:

在8周的基于跑步机的MICT和HIIT后,小鼠胃口肌肉的RNA测序 (RNA-seq).
群体之间的基因表达差异分析 (DEGs).
凯格路径分析和肌肉激素表达分析.

主要成果:

在HIIT和MICT组之间,确定了1052个差异表达基因 (DEG).
关键基因Foxo1和Myod1是最重要的DEGs之一.
在FoxO,MAPK和PI3K-AKT信号传输中观察到明显的途径丰富.
与HIIT相比,MICT组的胰岛素样生长因子1 (Igf-1) 表达显著更高.

结论:

在骨肌肉中,MICT和HIIT诱导了独特的转录基因特征.
胰岛素类生长因子1 (IGF-1) 可能在介导MICT和HIIT之间的不同肌肉适应方面发挥关键作用.
作为上游调节剂,IGF-1可能会影响PI3K-AKT-FoxO和MAPK通路,导致明显的运动诱导肌肉可塑性.

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