降低IV级新生儿重症监护病房整体抗生素使用率
Reema Paul1, Dipen Vyas1,2, Vilmaris Quinones Cardona1
1Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Pediatrics
|February 25, 2025
概括
新生儿重症监护室 (NICU) 的抗生素使用量通过管理计划显著减少了50%. 这涉及实施共识指南和标准化文档,有效降低整体和培养负性败血症的抗生素利用率 (AUR).
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素经常在新生儿重症监护室 (NICU) 处方,主要用于培养负性败血症.
- 减少抗生素的使用是NICU对抗抗菌素耐药性的关键目标.
研究的目的:
- 在4年内将IV级NICU的整体抗生素利用率 (AUR) 降低20%
- 实施抗生素管理质量改善倡议.
主要方法:
- 一个多学科团队制定了关于抗生素持续时间的共识指南.
- 干预措施包括教育课程,抗生素停用日期,以及针对抗生素必要性的电子健康记录文件.
主要成果:
- 总体而言,AUR下降了50% (从278到140的DOT/1000-PD).
- 培养负性败血症诊断的AUR下降了64% (从22到8个DOT/1000-PDs).
- 在两周内重新开始抗生素治疗的情况保持不变.
结论:
- 在NICU的抗生素共识指导方针和教育有效地减少抗生素在高急性人群中的安全使用.
- 多学科的支持和标准化的电子健康记录文档提高了合规性,并促进了持续的抗生素减少.
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