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在基本高血压中,左心室结构和功能的纵向变化与24小时尿液自由皮质醇之间的关联
Gao-Zhen Cao1,2, Jia-Yi Huang2,3, Qing-Shan Lin4
1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Journal of clinical hypertension (Greenwich, Conn.)
|February 25, 2025
概括
24小时尿中皮质醇水平升高 (24h-UFC) 与基本高血压中不良心脏变化有关. 高皮质醇与左心室质量增加和腹功能障碍有关,表明心脏健康状况较差.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
背景情况:
- 基本高血压是心血管疾病的主要危险因素.
- 皮质醇是一种压力激素,在心血管调节中起作用.
- 心脏结构和功能的微妙变化可能会在明显心力衰竭之前发生.
研究的目的:
- 调查24小时尿皮质醇水平 (24小时UFC) 与左心室 (LV) 重塑和功能在基本高血压之间的关联.
- 为了确定皮质醇升高是否是心脏不良变化的独立预测因素.
主要方法:
- 对315名基本高血压患者进行前性队列研究.
- 基线24小时UFC测量和心声回声 (LVM,LVEF,E/e'比率).
- 随访时间平均为28.54个月,分析24小时UFC第三种动物中LV参数的变化.
主要成果:
- 较高的基线24小时UFC水平与增加的LVM和E/e'比率相关.
- 经过对混因素进行调整后,关联仍然很重要.
- 最高的24小时UFC三角动物与较低的三角动物相比,显示LV缩的患病率增加.
结论:
- 升高的24小时UFC独立地与本质高血压中不良的LV结构和功能变化有关.
- 皮质醇可能有助于心脏重塑和腹功能障碍.
- 这些发现强调了监测高血压患者的皮质醇对心血管风险评估的重要性.
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