男性吸烟对IVF/ICSI后成功率的影响
S De Brucker1, E Dhooge1, P Drakopoulos1
1Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
概括
男人吸烟似乎不会对经过体外受精 (IVF) 或细胞内精子注射 (ICSI) 的夫妇的活产率产生负面影响. 在调整关键因素后,这项大型研究没有发现任何显著的关联.
科学领域:
- 生殖医学和辅助生殖技术 (ART)
- 男性不孕症和环境因素
- 临床胚胎学和研究成果研究成果
背景情况:
- 男人吸烟对精液质量和生殖结果的确定的负面影响.
- 需要澄清男性吸烟对辅助生殖成功率的具体影响.
研究的目的:
- 研究男性吸烟对体外受精 (IVF) 和细胞内精子注射 (ICSI) 结果的影响.
- 为了确定男性吸烟状态是否会影响第一次ART周期的不育夫妇的活产率 (LBR).
主要方法:
- 追溯分析了4004对不孕夫妇,他们与非吸烟女性伴侣进行了第一次试管婴儿/ICSI周期.
- 对男性伴侣的吸烟评估,分为轻度,中度和重度吸烟.
- 测量的主要结果是活产率 (LBR),并对女性年龄,BMI和ART参数等混因素进行调整.
主要成果:
- 原始分析显示,与非吸烟者相比,吸烟者具有更高的阳性hCG和LBR.
- 经过对混因素进行调整后,男性吸烟状况与新鲜LBR没有显着的关联 (OR = 1.16,CI = 0.92-1.48).
- 在调整后,吸烟水平的分类 (轻度,中度,重度) 也没有显示出与LBR有显著的关联.
结论:
- 在接受IVF/ICSI治疗的夫妇中,男性吸烟似乎不会影响活产率.
- 这些发现表明,在控制其他变量时,男性吸烟可能不是ART成功的显著负面因素.
相关概念视频
01:23Infertility in Males
228
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
228
01:41Spermatogenesis
102.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.0K
01:24In Vitro Fertilization
188
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
188
01:28Infertility in Females
256
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
256
02:07Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
01:57Meiosis II
182.0K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
182.0K