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Updated: May 26, 2025

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
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Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

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由Aβ组件的过渡状态依赖的自发生成编码了聚合物形成的自我调节的正反循环

Michael W Chen1, Xiaokang Ren1, Xiaowei Song2

  • 1Department of Biomedical Engineering and Center for Biomolecular Condensates, Washington University in St. Louis, Saint Louis, Missouri 63130, United States.

Journal of the American Chemical Society
|February 25, 2025
PubMed
概括

氨基酸β (Aβ) 组合通过氧化还原活性产生活性氧物种,从而导致神经毒性和聚合. 这一发现为阿尔茨海默病及相关疾病提供了新的治疗点.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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