塞拉基醇和 kazeinate 的纳米复合物:制剂,物理化学性质和相互作用机制
Junbo He1, Xinyu Zhang2, Yijie Li2
1Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China; Engineering Research Center of Lipid-based Fine Chemicals of Hubei Province, Wuhan 430023, China.
Food chemistry
|February 25, 2025
概括
塞拉基尔酒精 (SA) 的溶解性通过与 kazeinate (NaCas) 复合而得到改善. 由此产生的SA-NaCas纳米复合体为潜在的纳米输送应用提供了增强的物理化学特性.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 塞拉基醇 (SA),一种1-O-基糖醇,表现出多种生物活性,但水溶性差.
- 提高生物活性脂质的可溶性对于其有效的输送和应用至关重要.
- 酸 (NaCas) 是一种著名的食品蛋白质,具有乳化特性.
研究的目的:
- 调查塞拉基醇 (SA) 与 kazeinate (NaCas) 的复合,以提高SA的水溶性.
- 为了描述由此产生的SA-NaCas复合物的物理化学特性.
- 探索SA-NaCas综合体作为纳米输送系统的潜力.
主要方法:
- 在不同质量比下,SA与NaCas的复合.
- 使用表面疏水性,动态表面张力和乳化指数对SA-NaCas复合物的表征.
- 光谱法以阐明相互作用机制和热力学.
- 分子对接模拟以确定SA和素成分之间的结合相互作用.
主要成果:
- 最佳的复合物形成发生在SA与NaCas的质量比为1:4时.
- SA-NaCas复合物形成了一个纳米尺度的分散,其表面疏水性增加,动态表面张力降低.
- 与单独的NaCas相比,SA-NaCas复合体的乳化指数更高.
- 光谱学表明SA和NaCas之间存在自发的,疏水驱动的相互作用 (K = 1.17 × 103 L/mol, ΔG = -18.09 kJ/mol在308 K).
- 分子对接证实了SA和α-/β-素之间的疏水和键相互作用.
结论:
- 与NaCas的复合有效地提高了selachyl酒精的水溶性和物理化学特性.
- SA-NaCas纳米复合体作为一个有前途的纳米输送系统,具有改进的特性.
- 这些发现突出了使用蛋白质多糖化合物复合物的潜力,用于封装和输送脂性生物活性化合物.
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