对深呼吸呼吸持久和自由呼吸的系统审查,用于乳腺癌放射治疗的质子束疗法计划
F Wilson1, P Gupta2, H Halvorsen2
1Radiotherapy Related Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Patterson Building, Wilmslow Road, Manchester, M20 4BX, UK; The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.
概括
深呼吸喘息 (DIBH) 对大多数接受质子束疗法 (PBT) 的乳腺癌患者没有显著的益处. 需要进一步的研究来确定PBT与DIBH在放射治疗中的个体患者优势.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 质子束疗法 (PBT) 是一种先进的放射治疗技术.
- 深呼吸喘息 (DIBH) 是一种减少心脏和肺部剂量的方法,用于乳腺癌放射治疗.
- 将PBT与DIBH与自由呼吸 (FB) 进行比较对于优化治疗计划至关重要.
研究的目的:
- 在乳腺癌患者中系统地审查比较DIBH中的PBT与FB的研究.
- 分析DIBH和FB PBT计划之间风险器官的剂量差异.
主要方法:
- 对2015年至2023年间发表的研究进行系统审查.
- 包括对同一患者的DIBH和FB PBT计划进行比较的研究.
- 对风险器官的剂量进行比较.
主要成果:
- 分析了9篇论文和97名患者 (所有患者都接受左侧治疗).
- 平均心脏剂量在DIBH (0.31 Gy) 中低于FB (0.48 Gy).
- 在DIBH (5.27 Gy) 中,左肺的平均剂量高于FB (4.80 Gy).
- 平均LAD动脉剂量在DIBH (6.49 Gy) 中低于FB (8.74 Gy).
结论:
- 目前的文献表明,DIBH对大多数接受PBT的乳腺癌患者没有显著的剂量优势.
- 对于特定的患者,结合PBT和DIBH的潜在好处不能被排除.
- 需要进一步调查,以确定可能从DIBH与PBT中受益的患者子组.
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