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作为新型的SARS-CoV-2 RdRp抑制剂,发现和优化费纳索皮里丁化

Jianyuan Zhao1, Guoning Zhang1, YaSheng Li2

  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.

European journal of medicinal chemistry
|February 25, 2025
PubMed
概括

费纳索皮里丁化 (PAP) 有效地抑制了SARS-CoV-2的复制,并向病毒RNA依赖RNA聚合酶 (RdRp). 优化的衍生品显示出强大的抗病毒活性,为COVID-19疗法提供了一个有前途的途径.

关键词:
在 COVID-19 疫情中,纳索皮里丁化水化合物这是一种RdRp抑制剂.这就是SARS-CoV-2病毒.结构与活动之间的关系.综合合成 综合合成

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