最近被诊断为前列腺癌的患者冠状动脉化的预后影响
Nina Stødkilde-Jørgensen1,2, Andreas Bugge Tinggaard1,2, Simon Winther2,3
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Cardiology
|February 25, 2025
概括
患有前列腺癌的患者患心血管事件的风险更高. 来自CT扫描的冠状动脉分数 (CACS) 可以识别那些死亡,心脏病发作或中风风险增加三倍的人.
科学领域:
- 心血管成像 - 心血管成像
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 前列腺癌患者面临心血管事件风险升高.
- 非心电图的CT扫描评估冠状动脉化,但冠状动脉分数 (CACS) 的预后影响尚不清楚.
- 这项研究调查了CT扫描中的CACS及其与前列腺癌患者主要心血管不良事件的关联.
研究的目的:
- 在前列腺癌患者的CT扫描中确定CACS的预后值.
- 评估CACS水平与所有死因,心肌梗塞或中风风险之间的关联.
- 确定针对心血管疾病预防策略的高风险个人.
主要方法:
- 分析了571名前列腺癌患者,没有先前冠状动脉疾病,接受PSMA PET/CT.
- 分为四个CACS组的分层:0-10,11-99,100-399,以及≥400.
- 利用考克斯比例危险模型,根据风险因素进行调整,以评估CACS和结合终点相关性.
主要成果:
- 在CACS组中的分布:0-10 (26%),11-99 (21%),100-399 (24%),≥400 (29%).
- 增加的CACS与结合终点的风险增加相关.
- 与CACS 0-10相比,CACS 100-399和≥400的危险比分分别为2.39和3.14,相比之下,CACS 0-10的危险比分分别为2.39和3.14.
结论:
- 从初始PET/CT扫描中进行的CACS评估发现前列腺癌患者的死亡,心脏病发作或中风风险增加了三倍.
- 在高CACS患者的预防性他类药物治疗可以减轻心血管事件.
- 常规CACS评估可以帮助前列腺癌患者的风险分层和心血管并发症的管理.
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