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西亚苏开在肝细胞癌中通过肠肝轴发挥抗发育作用

Ting Zhou¹, Liyuan Pei², Ya Chen²

¹Department of Clinical Chinese Pharmacy, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

|February 25, 2025

概括

(XYXD) 能够通过改善肠道微生物群多样性和修复肠道屏障来抑制肝细胞癌 (HCC) 的进展. 这种传统中医药对肠道微生物群产生影响,减少HCC小鼠的炎症和免疫细胞透.

科学领域:

胃肠病学和肝病学
微生物学微生物学
在瘤学瘤学.

背景情况:

肠肝轴在肝细胞癌 (HCC) 的发展中起着至关重要的作用.
肠道微生物群失调与HCC病变发生有关.
苏 (XYXD) 对HCC的治疗效果尚不清楚.

研究的目的:

在小鼠模型中研究XYXD对HCC进展的影响.
探索 XYXD 的作用背后的机制,专注于肠肝轴和肠道微生物群.

主要方法:

肝细胞癌 (HCC) 的小鼠模型被诱导使用二甲基胺和四化碳.
用XYXD治疗小鼠,并通过Hematoxylin-eosin染色来评估病理变化.
免疫组织化学,ELISA,免疫光和16SrRNA测序被用来分析分子和微生物的变化.

主要成果:

XYXD治疗抑制了HCC的进展,并上调了肠道屏障蛋白 (ZO-1,ocludin,claudin).
XYXD减少了巨细胞和中性粒细胞在结肠中的透,并降低了SIgA水平.
在HCC小鼠中XYXD调节肠道微生物群组成和增强的微生物多样性.

结论:

XYXD证明了对HCC进展的抑制作用.
XYXD通过调节肠道微生物群来起作用,从而调节肠道和肝脏的炎症和免疫反应.
这些发现突显了XYXD作为通过肠肝轴治疗HCC的治疗剂的潜力.

关键词:

我们的肠道微生物群.肝细胞癌是肝细胞癌.肠 - 肝轴肠 - 肝轴西亚苏的蒸.

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