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Updated: May 25, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

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通过重新激活免疫突触分子来增强抗瘤免疫力

Xindi Zhou1, Tian Xu2, Changhe Li1

  • 1State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.

Cell reports. Medicine
|February 25, 2025
PubMed
概括

瘤中ICAM-1的低表达阻碍了免疫突触的形成,导致对癌症免疫疗法的耐药性. 使用新型疗法恢复LFA-1信号克服了这一问题,增强了抗瘤免疫力,并与检查点封锁协同作用.

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