鱼类消费对多发性硬化症残疾进展的影响
Eva Johansson1, Jie Guo2, Jing Wu3
1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Journal of neurology, neurosurgery, and psychiatry
|February 25, 2025
概括
较高的鱼类消费与多发性硬化症 (MS) 中残疾进展的减缓有关. 保持一致的鱼类摄入量可能为MS患者提供保护性益处.
科学领域:
- 神经科学是一个神经科学.
- 营养流行病学 营养流行病学
- 临床神经学 临床神经学
背景情况:
- 饮食因素,包括鱼类摄入量,越来越多地被认为对多发性硬化症 (MS) 发展和进展的潜在作用.
- 研究特定的饮食成分,如鱼类对MS残疾的影响,对于了解疾病管理至关重要.
研究的目的:
- 检查鱼类消费与多发性硬化症 (MS) 患者残疾进展之间的关联.
主要方法:
- 使用了基于人口的病例控制研究 (多发性硬化症流行病学调查) 的数据,随访时间长达15年.
- 评估了鱼类摄入量和扩展残疾状态量表 (EDSS) 的结果,使用考克斯回归模型来分析残疾恶化 (CDW) 和进展到EDSS 3和EDSS 4.
- 整合了数字后续问卷以跟踪鱼类消费随时间变化的变化.
主要成果:
- 在诊断时食用较多的瘦鱼和油性鱼与确认残疾恶化的风险降低相关 (CDW),EDSS 3和EDSS 4.
- 经过对生活方式因素进行调整后,这些保护性关联仍然很重要,并且在增加鱼类摄入量时显示出明显的趋势.
- 在整个随访期内,持续的鱼类消费显示出增强的保护作用.
结论:
- 增加鱼类消费似乎与多发性硬化症 (MS) 中更有利的残疾进展有关.
- 饮食习惯,特别是鱼类摄入量,是管理多发性硬化症的潜在可修改因素.
- 建议在临床应用之前进行进一步的研究以验证.
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