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Updated: Jun 21, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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以结构为导向的RNF43/ZNRF3化学定制的结体的开发,以实现膜蛋白向PROTAC的多功能设计

Jibin Cui1, Qingyun Zheng1, Yicheng Weng1

  • 1Institute of Translational Medicine, School of Pharmacy, School of Biomedical Engineering, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Shanghai Jiao Tong University, Shanghai, 200240, China.

Angewandte Chemie (International ed. in English)
|February 25, 2025
PubMed
概括

研究人员为RNF43/ZNRF3 E3酶开发了新的结剂,使得膜蛋白的向降解成为可能. 这促进了蛋白质分解向仿真体 (PROTACs) 的发展,用于治疗具有挑战性的药物标,如PD-L1和EGFR.

关键词:
细胞表面E3结合酶.在化学上量身定制的降解剂.类结合剂 类结合剂合成和重新折叠富含二硫化物的.有针对性的膜蛋白降解降解.

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