抑郁症状的潜力,以识别衰老中的认知障碍
Panagiotis Alexopoulos1,2,3,4, Christos Bountoulis5, Everina Katirtzoglou6
1Department of Medicine, School of Health Sciences, Mental Health Services, Patras University General Hospital, University of Patras, 26504, Rio, Patras, Greece. panos.alexopoulos@upatras.gr.
European journal of ageing
|February 25, 2025
概括
抑郁症状可以帮助老年人识别认知障碍,包括轻度认知障碍 (MCI) 和阿尔茨海默氏症.
科学领域:
- 老年精神病学是一门精神病学专业.
- 认知神经科学 认知神经科学
- 医疗保健中的机器学习
背景情况:
- 在轻度认知障碍 (MCI),阿尔茨海默氏症痴呆症 (AD痴呆症) 和认知正常衰老中,抑郁症状很普遍.
- 抑郁症状在区分认知障碍与健康衰老中的作用尚不清楚.
研究的目的:
- 评估抑郁症状在区分健康的认知衰老与MCI和AD痴呆症中的有用性.
- 将抑郁症状尺度的诊断性能与标准认知评估进行比较.
主要方法:
- 利用对1737名认知不受损的个人,334名MCI患者和142名AD痴呆症患者的综合神经精神病学评估.
- 采用比例赔率逻辑回归 (POLR) 和自适应提升 (AdaBoost) 机器学习算法.
- 使用15项老年抑郁量表 (GDS) 测定抑郁症状,以及迷你精神状态检查 (MMSE) 测定认知功能.
主要成果:
- 使用GDS总得分的POLR模型实现了>78%的准确性,但与MMSE相比敏感性较低.
- 通过分析单个GDS项目,AdaBoost的准确度高于72%,与MMSE相美,具有平衡的灵敏度和特异性.
- 用AdaBoost分析的个别GDS项目在区分认知障碍方面表现出有希望.
结论:
- 抑郁症状,特别是使用机器学习单独分析时,显示出作为识别认知障碍的补充工具的潜力.
- 这项研究提供了初步证据,支持抑郁症状对认知衰老和认知障碍差异诊断的贡献.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
40
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
40
Cognitive Development During Adulthood
44
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
44
Depression: Overview
208
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
208
Depressive Disorders: Etiology
28
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
28
Depressive Disorders: MDD and Dysthymia
29
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
29
Cognitive Therapy
77
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
77


