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作为评估骨关节炎严重程度的非侵入性生物标志物的尿液4-pyridoxic酸:来自ROAD研究的发现

Noriko Yoshimura¹, Aiko Miyazaki², Toshiko Iidaka³

¹Department of Preventive Medicine for Locomotive Organ Disorders, 22ndMedical and Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. noripu2yoshi@gmail.com.

Aging clinical and experimental research

|February 25, 2025

概括

在日本成年人中,尿液中的4-pyridoxic酸 (4PA) 可能表明严重的膝关节骨关节炎 (KOA). 较高的4PA水平与晚期KOA有关,但与腰椎脊椎病 (LS) 严重程度无关.

科学领域:

发现生物标志物的发现.
骨关节炎的研究研究.
老年医学老年医学

背景情况:

早期发现骨关节炎 (OA) 是至关重要的,但由于缺乏可靠的生物标志物而受到限制.
目前用于OA严重程度的诊断方法需要改进,以便及时进行干预.

研究的目的:

调查尿液中的4-皮里多克酸 (4PA) 作为膝关节骨关节炎 (KOA) 和腰椎脊髓炎 (LS) 严重程度的潜在生物标志物.
在日本成年人中分析4PA水平与放射性骨关节炎严重程度之间的关联.

主要方法:

来自ROAD队列研究的1566名日本成年人 (≥40岁) 的数据分析.
膝盖和腰椎的放射评估,通过高性能液体染色学测量尿4PA.
后勤回归来评估4PA水平与KOA和LS的Kellgren-Lawrence (KL) 等级之间的联系.

主要成果:

与较低等级相比,KL 4级KOA的参与者观察到尿液中的4PA水平显著更高 (p < 0.001).
在调整了诸如年龄,性别,BMI和生活方式等混因素后,这种关联仍然存在.
在LS和KL等级之间没有发现4PA水平的显著差异,尽管KL等级4LS的KL水平略有增加.

结论:

尿4PA显示出作为评估KOA严重程度的生物标志物的潜力,特别是在晚期.
4PA可能有助于治疗严重KOA的治疗决策,包括手术干预.
使用4PA检测早期OA仍然具有挑战性.

关键词:

4 - 皮里多西克酸是什么?膝关节骨关节炎是一种关节炎.腰椎脊椎病是指腰椎脊椎病的一种疾病.基于人口的队列 ROAD 公路.预测性的生物标志物

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