通过基于小组的多轨迹建模,确定在住院老年护理中同时使用心理药物的长期模式和预测因素:"MEDTRAC-心理药物"纵向队列研究:基于小组的多轨迹建模
Nasir Wabe1, Isabelle Meulenbroeks2, Desiree Chantelle Firempong2
1Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, North Ryde, NSW, 2122, Australia. nasir.wabe@mq.edu.au.
European geriatric medicine
|February 25, 2025
概括
许多老年护理人员,特别是那些患有痴呆症的人,长期服用多种精神药物. 这种并发的使用,通常是多年来,会给健康带来重大风险,需要进一步调查适当性和改善结果.
科学领域:
- 老年学是一门学科.
- 心理药理学 心理药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 精神药物在居住老年护理设施 (RACF) 中被广泛处方.
- 在老年人中使用心理药物存在安全问题.
- 纵向的同时使用精神药物的模式并未得到充分理解.
研究的目的:
- 确定RACF居民同时使用抗抑郁药,抗精神病药和抗焦虑药/催眠药的轨迹.
- 为了确定这些药物的预测因素,使用轨迹.
- 为了比较患有痴呆症和没有痴呆症的居民之间的模式.
主要方法:
- 在30个悉尼RACF进行了回顾性纵向队列研究.
- 包括2837名永久居民 (≥65岁),其中1344人患有痴呆症.
- 监测了三年来每周对三种精神药物类别的暴露,使用基于组的多轨迹建模.
主要成果:
- 在基线时,同时使用多种类型的精神药物在痴呆症患者中为31.6%,在非痴呆症患者中为23.3%.
- 最佳模型确定了痴呆症的6个轨迹和非痴呆症队列的4个轨迹.
- 在非痴呆症居民中,轨迹通常稳定,但在痴呆症患者中变化更大.
结论:
- 三分之一的痴呆症患者和五分之一的没有痴呆症患者同时长时间使用多种精神药物.
- 这种长时间的并发使用可能会增加居民风险.
- 需要进一步的研究来评估适当性和改善健康结果.
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