来自Saccharomyces cerevisiae RC016细胞壁的后生物 (以前被归类为益生菌):探索体外和体外益处
Valeria L Poloni1,2, María Eugenia Pérez3,4, Franco Escobar3,5
1Departamento de Microbiología E Inmunología, Universidad Nacional de Río Cuarto, Ruta 36 Km 601, (5800), Río Cuarto, Cordoba, Argentina. vpoloni@exa.unrc.edu.ar.
Probiotics and antimicrobial proteins
|February 25, 2025
概括
这项研究从Saccharomyces cerevisiae细胞壁中产生了后生物,证明了它们在雄性小鼠中改善肠道健康和完整性的潜力. 这项研究还探索了它们的抗毒素能力,以对抗青素B1.
科学领域:
- 微生物学 微生物学
- 食品科学 食品科学 食品科学
- 动物科学动物科学
背景情况:
- 来自微生物的后生物,在没有微生物管理的情况下提供潜在的健康益处.
- 细胞壁中的Saccharomyces cerevisiae是生物活性化合物的丰富来源.
- 了解后生物的生产和有效性对于它们在动物料和人类健康中的应用至关重要.
研究的目的:
- 从Saccharomyces cerevisiae RC016细胞壁中获得和描述后生物.
- 评估体外抗毒素能力和体内对肠道完整性的影响.
- 分析干燥方法对毒素吸附特性的影响.
主要方法:
- 使用九种机械和酶处理方法从Saccharomyces cerevisiae RC016生物质中提取后生物质.
- 在体外研究中评估了抗毒素对阿弗拉托xin B1 (吸附和降解) 的活性.
- 在体内对BALB/c小鼠的研究评估了微生物群调节和肠道基因组学.
主要成果:
- 后生物体在体外表现出对阿弗拉托克辛B1.1的抗毒素活性.
- 在雄性和雌性小鼠之间观察到肠道微生物群的显著差异.
- 接受后生菌药物的雄性小鼠表现出的高度,宽度和密室深度增加.
结论:
- 来自Saccharomyces cerevisiae细胞壁的后生物可以积极影响肠道完整性,特别是在雄性小鼠中.
- 这项研究强调了这些后生菌作为功能成分的潜力.
- 进一步的研究可以优化生产并探索不同人群的更广泛应用.
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