血清代谢特征与结直肠腺瘤恶化相关
Ze Dai1,2,3,4, Tong Li5, Kecong Lai6
1Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315020, Zhejiang, China.
Scientific reports
|February 25, 2025
概括
血清代谢揭示了结直肠癌 (CRC) 阶段之间的明显差异. 晚期腺瘤 (AAs) 与CRC具有相似的代谢特征,这表明早期非侵入性诊断的潜力.
科学领域:
- 生物化学和分子生物学
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 结肠直肠癌 (CRC) 从结肠直肠腺瘤发展,被分类为非高级 (NAA) 和高级 (AA).
- 预测有很大的差异,NAA的复发率和死亡率低于AA或CRC.
- 血清代谢量显示CRC早期诊断的希望,但NAA与AA代谢差异需要阐明.
研究的目的:
- 在不同阶段使用血清代谢指纹探索CRC发育机制.
- 发现一种基于血清代谢的新型非侵入性CRC诊断方法.
- 阐明非高级腺瘤 (NAA) 和高级腺瘤 (AA) 之间的血清代谢物组成差异.
主要方法:
- 建立了一个临床队列:健康对照 (NC),NAA,AA和CRC组.
- 使用液体染色学/质谱学 (LC/MS) 进行了非向的代谢组分析.
- 利用LASSO回归和随机森林算法进行代谢物选择和诊断模型构建.
主要成果:
- 在NC/NAA组和CRC组之间观察到显著的代谢物差异.
- 在AA组的血清代谢物与CRC组的血清代谢物相似.
- 与NAA患者相比,在AA/CRC患者中鉴定出33种显著不同的代谢物,涉及脂质和咖啡因代谢.
- 使用随机森林的诊断模型显示NC/NAA和AA/CRC组之间存在强烈的歧视 (AUC为1,000培训,0.685测试).
结论:
- 血清代谢物组成是特定于结直肠癌发展的不同阶段.
- 晚期腺瘤 (AA) 呈现出与结直肠癌 (CRC) 类似的血清代谢物概况.
- 基于血清代谢物的诊断显示出引导腺瘤后续和治疗决策的潜力.
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