重新思考儿科呼吸道感染:混合病原体感染的作用
Jinjin Wang1,2, Ran Wang1,2, Zhengde Xie1,2
1Laboratory of Infection and Virology, Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China.
在儿童急性呼吸道感染 (ARI) 中,多种病毒不会加剧严重程度. 然而,病毒-细菌感染可能会增加儿童ARI的严重程度,影响治疗策略.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 急性呼吸道感染 (ARI) 是全球儿童疾病和死亡的主要原因.
- 分子诊断的进步增加了儿科ARI多种病原体的检测.
- 混合感染对儿童ARI严重性的影响尚不清楚.
研究的目的:
- 审查当前关于混合病原体感染对儿科ARI严重性影响的研究.
- 澄清病毒-病毒与病毒-细菌共感染对疾病结果的影响.
- 为了为儿科ARI的诊断和治疗策略提供信息.
主要方法:
- 现有科学文献的叙述性审查.
- 对报告小儿ARI病原体共检测率的研究进行分析.
- 综合关于混合感染和疾病严重程度之间的关系的发现.
主要成果:
- 在儿科ARI中多种病毒的同时检测率差异很大 (0.07%55%).
- 多种病毒共感染并没有显著增加儿童的ARI严重程度,可能是由于病毒干扰或免疫调节.
- 混合的病毒和细菌感染可能会通过诸如增强的炎症和受损的修复等机制加剧ARI的严重程度.
结论:
- 与多种病毒的同时感染似乎不会增加儿童ARI的严重程度.
- 细菌-病毒共感染可能会加剧儿科ARIs,需要在诊断和治疗中仔细考虑.
- 更好地了解混合感染可以提高诊断精度和治疗,减少并发症和死亡率.
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