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Updated: May 11, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
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一个在单细胞分辨率下解析的26个基因的空间转录基因签名,标志着高风险的胃癌前体

Robert J Huang1, Ignacio A Wichmann2,3,4, Andrew Su5

  • 1Division of Gastroenterology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA.

NPJ precision oncology
|February 25, 2025
PubMed
概括

胃肠道转化成形的进展有所不同. 异常肠道细胞中26个基因的特征表明不成熟的血统在高风险前体致癌中的作用,有助于胃癌预防策略.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...