探索甲状腺功能低下症和代谢功能障碍相关的脂肪性肝病之间的联系:英国生物银行队列研究
Haitao Wang1, Changlin Zheng2, Peisong Wang3
1Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Scientific reports
|February 25, 2025
概括
患有甲状腺功能低下症的人面临着明显更高的患有代谢功能障碍相关脂肪肝疾病 (MASLD) 的风险. 炎症和代谢标志物在这种关联中发挥着关键作用,突出显示了对甲状腺功能低下患者肝脏监测增加的必要性.
科学领域:
- 肝病学和内分泌学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MASLD),以前称为NAFLD,是一个日益严重的全球健康问题,患病率越来越高.
- 甲状腺功能低下症和MASLD之间的关联是复杂的,观察性研究的发现仍然不一致.
- 了解这种关系对于识别风险人群和为临床实践提供信息至关重要.
研究的目的:
- 系统地调查甲状腺功能低下症和MASLD发病率之间的关联.
- 探索这种关系中的潜在调解因素和效果修饰因素.
- 提供证据,以加强对低甲状腺患者肝脏健康的临床监测.
主要方法:
- 利用来自英国大型生物银行队列的前性数据.
- 采用了Cox的比例危险模型与灵敏度分析.
- 进行了分层分析,调解分析和受限立方线回归.
主要成果:
- 经过对共变量进行调整后,甲状腺功能低下症显著增加了1.711倍的MASLD风险 (95%CI为1.711,P<0.001).
- 非手术相关的甲状腺功能低下症 (NSRH) 和手术相关的甲状腺功能低下症 (SRH) 都与MASLD风险增加有关.
- 红细胞分布宽度,C-反应蛋白,HbA1c和总蛋白被确定为重要的调解因素.
结论:
- 甲状腺功能低下是发展MASLD的一个重要危险因素.
- 炎症和代谢生物标志物调解了甲状腺功能低下症和MASLD之间的联系.
- 强化肝功能监测是推给甲状腺功能下降患者,以使早期MASLD检测和干预.
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