代谢综合征包括血压升高和空腹血葡萄糖升高,与较高的死亡风险有关:一项前性研究
Shu Li1,2,3, Chi Pang Wen4, Huakang Tu1
1Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
代谢综合征 (MetS) 与血压升高和空腹血葡萄糖 (BG型MetS) 显著增加所有原因,癌症和心血管疾病的死亡风险. 针对BG型MetS的个体是改善健康结果的关键.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 长寿研究研究 长寿研究
背景情况:
- 代谢综合征 (MetS) 是一种代谢异常的集群.
- 确定具有最高死亡风险的MetS组件组合是必不可少的.
- 了解MetS组件和寿命之间的因果关系是一个关键的研究领域.
研究的目的:
- 为了确定哪种特定组合的 MetS 组件构成最大的死亡风险.
- 调查MetS组件与寿命之间的因果关系.
主要方法:
- 对340,196名参与者的前性分析,以及对121,936.6名参与者的随访数据.
- 根据 NCEP ATP III 标准定义的 MetS.
- 考克斯比例危险模型和多变量门德尔随机化 (MVMR) 用于分析死亡率 (心血管疾病,癌症,各种原因) 和寿命.
主要成果:
- 血压升高是所有原因,癌症和心血管疾病死亡的主要危险因素.
- 与其他类型的MetS相比,患有BG型MetS (高血压和空腹血葡萄糖) 的参与者表现出明显更高的死亡风险 (44%全因,73%癌症,34%心血管疾病).
- MVMR表明,由于基因的作用,缩性BP和FPG的增加降低了达到90岁的可能性.
结论:
- 与其他MetS呈现相比,BG型MetS与死亡风险相对较高.
- 建议针对BG型MetS患者的干预措施,以减轻不良健康结果并改善生存率.
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