儿科重症监护病房中的抗菌药物管理计划:系统范围审查
Cecilia Liberati1, Giulia Brigadoi1, Elisa Barbieri1
1Division of Paediatric Infectious Diseases, Department of Women's and Children's Health, University of Padova, 35128 Padua, Italy.
Antibiotics (Basel, Switzerland)
|February 26, 2025
概括
在儿科重症监护室 (PICU) 的抗菌药物管理计划 (ASP) 是有希望的,但缺乏标准化的指标. 协调报告对于比较抗微生物药物有效性和改善重症儿童抗微生物药物使用至关重要.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 传染性疾病 传染性疾病
- 医疗保健管理的管理
背景情况:
- 抗微生物药物管理计划 (ASP) 和诊断管理计划 (DSP) 对于打击抗微生物药物耐药性至关重要.
- 在儿科重症监护室 (PICU) 实施这些计划是必不可少的,但可能面临独特的挑战.
研究的目的:
- 审查和总结ASP和DSP的当前实施状态,特别是在PICU内.
- 在儿科重症监护机构中确定与这些管理计划相关的共同战略,结果和挑战.
主要方法:
- 从2007年到2024年,主要数据库 (Embase,MEDLINE,Scopus,Cochrane图书馆) 进行了系统的文献搜索.
- 包括评估在PICU中ASP或DSP实施的研究,并使用标准化表格提取数据.
- 包含的参考文献使用Rayyan软件进行管理和选.
主要成果:
- 包括18项研究:13项专注于ASP,5项专注于DSP.
- 大多数ASP研究报告了对抗微生物消费的积极影响,经常使用说服力策略.
- 在干预类型,结果指标和研究设计中观察到显著的异质性,限制了直接比较.
- DSP研究主要研究生物标志物和病原体检测,对抗生素处方的影响有限.
结论:
- 在PICU中ASP的实施正在进行中,但仍然有限,结果测量有相当大的变化.
- 协调报告指标对于比较计划有效性和优化PICU中的抗菌药物管理策略至关重要.
- 需要进一步的研究,以建立儿童重症监护诊断管理的最佳实践.
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