产生毒素的抗菌素敏感性Corynebacterium diphtheriae和C. 在比利时的
Zan Janssen1, Helena Martini1, Robin Vanstokstraeten1
1National Reference Center for Toxigenic Corynebacteria, Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.
Antibiotics (Basel, Switzerland)
|February 26, 2025
概括
斑疹炎的复苏与新兴的抗生素耐药性有关. 青素和类固醇仍然有效,但对*Corynebacterium diphtheriae*和*C. ulcerans*的耐药性检测对于有效的管理至关重要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 尽管疫苗接种和治疗,但欧洲的白喉病发病率正在上升.
- 对青素和类药物的新兴耐药性使得白喉病的管理变得复杂.
- 有毒的 *Corynebacterium diphtheriae* 和 *C. ulcerans* 需要更新敏感性概况.
研究的目的:
- 评估和比较 *C. diphtheriae* 和 *C. ulcerans* 的抗生素敏感性.
- 评估抗微生物耐药性基因/突变与表型耐药性之间的相关性.
- 确定不同抗微生物敏感性测试方法的可靠性.
主要方法:
- 追溯性研究分析抗生素敏感性.
- 使用的微稀释,磁盘扩散和梯度扩散方法.
- 全基因组测序 (WGS) 用于检测耐药性基因和突变.
主要成果:
- 在*C. diphtheriae*中观察到对三甲-硫甲醇 (85%),四环素 (38%) 和西普罗夫洛克萨 (29%) 的高耐药率.
- *C. ulcerans*对大多数抗生素表现出敏感性,对克林达米辛具有天然耐药性.
- 扩散技术显示了可接受的相关性,但对某些抗生素产生了错误的敏感结果.
结论:
- 青素和宏类药物仍然是白病的第一线治疗方法.
- 对所有有毒性*C. diphtheriae*和*C. ulcerans*分离物进行抗菌感应性测试是必不可少的.
- 测试应该包括除了青素和类药物之外的抗生素,WGS应该包括耐药性基因分析.
相关概念视频
01:23Antimicrobial Proteins
867
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
867
00:43Lysogenic Cycle of Bacteriophages
61.7K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
61.7K
00:57Antibiotic Selection
52.2K
Overview
52.2K
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:17Antidotes
604
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
604