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打击生产金属β-乳糖酶的 Pseudomonas aeruginosa: 分数抑制度指数作为评估抗生素协同作用的工具

Guido Granata¹, Carolina Venditti², Claudia Rotondo²

¹Systemic and Immune Depression-Associated Infection Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Via Portuense 292, 00149 Rome, Italy.

Antibiotics (Basel, Switzerland)

|February 26, 2025

概括

塞菲德罗科尔与伊米佩内姆-relebactam结合显示了对金属β-乳糖酶产生Pseudomonas aeruginosa感染的协同效应. 这种组合为难以治疗的格拉姆阴性细菌感染提供了有希望的治疗选择.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

越来越多的抗药性格拉姆阴性细菌,特别是那些产生金属β-乳酸酶的细菌.
治疗难以治疗和耐药的*Pseudomonas aeruginosa*引起的感染的挑战.

研究的目的:

描述了三例P. aeruginosa*感染的病例,这些病例成功地用Cefiderocol加Imipenem-relebactam治疗.
为了研究P. aeruginosa*分离物的分子和流行病学特征.
评估抗生素组合的体外协同效应,以指导治疗.

主要方法:

从临床样本 (呼吸道或血液培养) 中分离和鉴定三种P. aeruginosa*菌株.
使用EUCAST指南的最小抑制度 (MIC) 断点解释.
下一代测序用于抗性基因识别,序列类型和核心基因组多位置序列类型.
分数抑制度指数 (FICI) 用于评估抗生素协同作用.

主要成果:

隔离物表现出多种多药耐药性,携带blaIMP-13 (两个隔离物) 或blaVIM-2 (一个隔离物).
分子类型表示不同的序列类型,没有聚类的证据.
塞菲德罗科尔与伊米-relebactam 对两种产生IMP-13的分离物 (Pse-1和Pse-3) 具有协同作用,但对产生VIM-2的分离物 (Pse-2) 没有.

结论:

塞菲德罗科尔与伊米佩内姆-relebactam结合,显示了对产生IMP的P. aeruginosa*的协同活性.
这种组合代表了针对特定的金属β-乳糖酶产生*P. aeruginosa*感染的潜在治疗策略.
需要对更多的药物和分离物进行进一步的研究,以确认新的协同作用组合及其临床实用性.

关键词:

IMP-13 碳烯基质量测试结果 VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim 维罗纳整体编码的金属β-乳酸酶.抗生素治疗抗生素治疗抗微生物药物管理管理抗微生物药物的协同作用血流感染感染感染耐卡巴胺的 Pseudomonas aeruginosa 病毒塞菲德罗科尔 (Cefiderocol) 是一种麻醉药可以释放药物.金属β-乳酸酶的使用.

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