与代谢功能障碍相关的脂肪性肝病:与心血管风险的病原遗传联系
Vlad Alexandru Ionescu1,2, Gina Gheorghe1,2, Nicolae Bacalbasa3,4
1Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Biomolecules
|February 26, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 通过炎症和胰岛素抵抗等复杂机制显著提高心血管风险. 了解这些联系对于管理MASLD患者的心脏病至关重要.
科学领域:
- 肝病学和心脏病学.
- 代谢和心血管研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越被认为是心血管疾病 (CVD) 的重要独立风险因素.
- MASLD和心血管疾病之间的复杂关系涉及多个相互连接的病理生理路径.
- 心血管并发症是诊断为MASLD的个体死亡的主要原因.
研究的目的:
- 审查有关MASLD与心血管风险之间的关联的当前数据.
- 阐明病原性机制,将MASLD与心血管疾病发病率和死亡率的增加联系起来.
- 强调需要提高公众意识,并进一步研究MASLD对心血管的影响.
主要方法:
- 关于MASLD和心血管风险的最新研究的综合文献综述.
- 分析拟议的致病机制,包括内脏脂肪,炎症,氧化应激,内皮功能障碍和胰岛素抵抗.
- 对MASLD患者心血管结果的流行病学数据的检查.
主要成果:
- MASLD与冠状动脉疾病,动脉疾病,心脏异常和心律失常的更高发病率密切相关.
- 关键的促成机制包括内脏脂肪,低度炎症,氧化应激,内皮功能障碍,胰岛素抵抗,脂质不良,肠道失调以及遗传因素.
- 心血管疾病是MASLD人口的主要死亡原因.
结论:
- MASLD显著增加了心血管风险,独立于传统的风险因素.
- 了解复杂的致病机制对于开发向疗法和生物标志物至关重要.
- 提高认识和开展进一步的研究对于减少MASLD患者心血管疾病发病率和死亡率至关重要.
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