在患有自闭症和同时出现胃肠道症状的儿童中,改变单细胞群和激活标志物的表达
Rachel J Moreno1,2, Yasmin W Azzam1,2, Serena Eng1,2
1Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA.
Biomolecules
|February 26, 2025
概括
自闭症谱系障碍 (ASD) 中的免疫细胞差异与胃肠道 (GI) 症状有关. 患有自闭症和肠道疾病的儿童表现出改变的单细胞子集,可能会影响免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 神经发育障碍 神经发育障碍
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 影响36个美国儿童中的1个,其特点是社会沟通缺陷和重复行为.
- 许多患有自闭症的儿童经历了焦虑,多动症和严重的胃肠道 (GI) 问题等并发症.
- 在ASD中经常观察到免疫调节失调,包括高水平的促炎细胞因子和改变的先天免疫反应.
研究的目的:
- 调查ASD儿童单细胞子集频率的差异.
- 为了确定ASD儿童的胃肠道症状是否改变单细胞子集的分布.
- 探索单细胞亚群在与ASD相关的免疫失调中的作用.
主要方法:
- 来自患有ASD (有或没有胃肠道症状) 和典型发育 (TD) 控制的儿童的外周血液单核细胞的流细胞计分析.
- 对单细胞子集标识符 (CD14,CD16) 和激活标记器 (CCR2,HLA-DR,PD-1,PD-L1) 的染色.
- 研究小组之间的单细胞亚种群频率和标志物表达的比较.
主要成果:
- 与TD儿童相比,在ASD儿童中发现了单细胞亚群和表面标志物表达的显著变化.
- 单细胞组成的差异取决于胃肠道症状的存在或不存在.
- 与ASD+GI-和TD组相比,患有ASD和GI+症状 (ASD+GI+) 的儿童表现出明显的单细胞形状,包括较低的过渡性和非经典单细胞以及具有疲劳标记的经典单细胞 (PD-1,PD-L1) 的增加.
结论:
- 在ASD中,单细胞亚群的比例差异和表面标记物表达的改变可能导致观察到的免疫失调.
- 胃肠道症状在ASD中的存在与单细胞子集的特定变化有关,这表明肠道健康和免疫状态之间存在联系.
- 这些发现突显了单细胞在ASD病理生理学及其相关并发症中的潜在作用.
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