Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

476
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
Glomerular Filtration01:15

Glomerular Filtration

4.7K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
4.7K
Renal Corpuscle01:20

Renal Corpuscle

6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

19.9K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
19.9K
Nephrons01:10

Nephrons

6.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.

Archives of medical research·2018
Same author

Comparative genomics of 84 Pectobacterium genomes reveals the variations related to a pathogenic lifestyle.

BMC genomics·2018
Same author

Performance and microbial community analysis of an algal-activated sludge symbiotic system: Effect of activated sludge concentration.

Journal of environmental sciences (China)·2018
Same author

Draft Genome Sequence of Phaeobacter sp. Strain JL2872, Isolated from Surface Waters in the South China Sea.

Microbiology resource announcements·2018
Same author

Unconventional Facial Entry Points Confirmed Using a 3D CT Reconstruction-Guided Stereotactic Approach to Radiofrequency Thermocoagulation for the Treatment of Trigeminal Neuralgia: A Series of Case Reports.

Pain medicine (Malden, Mass.)·2018
Same author

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice.

Journal of neurochemistry·2018

相关实验视频

Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

使用分布式图数据库存储和查询药物知识图:一个案例研究.

Xingjian Han1, Yu Tian2

  • 1China Electronic Product Reliability and Environmental Testing Research Institute (The Fifth Electronic Research Institute of MIIT), Guangzhou 510610, China.

Bioengineering (Basel, Switzerland)
|February 26, 2025
PubMed
概括
此摘要是机器生成的。

分布式图表数据库在存储和查询大型药物知识图表方面明显优于单机系统. 这项技术通过提供可靠,可解释的药物疾病途径来增强药物重用研究.

关键词:
分布式图形数据库分布式图形数据库药物知识图表 药物知识图表实时数据检索 实时数据检索存储和查询可以进行.

更多相关视频

Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

相关实验视频

Last Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476
Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算化学的计算化学
  • 药物发现 药物发现 药物发现

背景情况:

  • 大规模的药物知识图对药物研究至关重要,但它们的存储和查询存在挑战.
  • 分布式图形数据库为管理复杂路径查询提供了一个有希望的解决方案.
  • 在评估这些数据库对药物知识图表的性能方面存在研究差距.

研究的目的:

  • 评估分布式图形数据库的可行性和性能,用于管理大规模的药物知识图形.
  • 评估基于Nebula Graph构建的药物知识图表系统的存储和查询性能.
  • 通过已建立的基准来验证该系统在药物再利用中的实用性.

主要方法:

  • 设计了一个使用Nebula Graph数据库的药物知识图存储和查询系统.
  • 在数据写入和查询执行方面评估了系统的性能.
  • 采用了两种药物重用基准 (repoDB和DrugRepoBank) 进行全面评估.

主要成果:

  • 分布式图形数据库在数据写入,常规查询,受约束查询和并发查询方面表现优于单机数据库.
  • 写作性能优势随着数据量增加而增加,查询性能优势随着任务的复杂性而增长.
  • 药物重定向基准确定了78.54%的途径与已批准的治疗方法相一致,以及12种潜在的新药指示,文献支持.

结论:

  • 开发的系统有效地构建,存储和查询广泛的多源药物知识图表.
  • 该系统提供可靠和可解释的药物疾病路径,支持药物重用倡议.
  • 分布式图表数据库是大规模药物知识图表管理的可行和高性能解决方案.