睡眠不足和物质使用障碍:从青少年到成年人的问题
Ana Clementina Equihua-Benítez1, Rodolfo Espinoza-Abad2, Fabio García-García1
1Biology Sleep Laboratory, Biomedicine Department, Health Sciences Institute, Veracruzana University, Xalapa 91190, Ver, Mexico.
Behavioral sciences (Basel, Switzerland)
|February 26, 2025
概括
睡眠不足是一个全球性问题,尤其对青少年来说,它与增加的物质使用有关. 一个过度活跃的氧化系统可能会驱动这种联系,可能导致青少年时期的成.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 青少年医学 青少年医学
背景情况:
- 失眠和睡眠障碍在全球普遍存在,影响一般人群和青少年.
- 睡眠障碍与发展物质使用障碍 (SUD) 的风险之间存在着令人担忧的双向关系.
- 全球物质消费,特别是酒精,尼古丁和大麻的消费正在增加,青少年发病率显著增加.
研究的目的:
- 探索睡眠不足与使用物质发展障碍风险增加之间的联系.
- 调查氧系统在睡眠障碍与SUD相关性中的潜在作用.
- 确定青春期是建立不适应循环的关键时期,这些循环可能会使个人倾向于SUD.
主要方法:
- 审查关于睡眠障碍,物质使用和氧化系统的现有文献.
- 对研究的分析,研究了色激素抗剂对失眠症状的影响.
- 对有毒物质使用史的个体中素神经元活动的死后研究的审查.
主要成果:
- 有证据表明,睡眠问题与对物质使用障碍的敏感性增加之间存在联系.
- 素激素系统的调节失调是相关的,因为素抗剂在治疗失眠方面表现有前途.
- 尸体解剖研究显示,习惯性阿片类药物使用者中素免疫反应神经元升高,这表明这种系统有作用.
结论:
- 青春期可能是一个关键的发育窗口,在这个窗口中,睡眠不足和氧系统之间的相互作用可以启动通往物质使用障碍的途径.
- 准氧系统可以为睡眠障碍和SUD预防/治疗提供潜在的治疗途径.
- 了解这种联系对于旨在缓解青少年吸毒率上升的公共卫生战略至关重要.
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