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高迷酸含量Melissa officinalis L.植物复合物调节由高葡萄糖诱导的微神经炎症

Giacomina Videtta¹, Chiara Sasia¹, Nicoletta Galeotti¹

¹Department of Neurosciences, Psychology, Drug Research and Child Health (Neurofarba), Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.

Antioxidants (Basel, Switzerland)

|February 26, 2025

概括

梅丽莎花 (Melissa officinalis,MO) 和罗斯马林酸 (Rosmarinic acid,RA) 可以减少微质中高血糖引起的神经炎症. 这种天然化合物通过平息大脑中的炎症反应来保护糖尿病相关的神经损伤.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

糖尿病的高血糖症可以通过激活微质细胞和促进神经炎症引起神经复杂症.
自然疗法中的化合物显示出降低微质介导的神经炎症的潜力.

研究的目的:

为了研究梅丽莎 officinalis (MO) 植物复合物的疗效,丰富在迷酸 (RA),在缓解高血糖引起的神经炎症在微质.
评估MO对高葡萄糖诱导的神经元损伤的神经保护作用.

主要方法:

BV2微质细胞和SH-SY5Y神经元细胞被暴露在高葡萄糖 (HG) 条件下.
进行了形态分析和生物化学测定,以评估微质激活标志物 (CD11b,NF-κB,iNOS,ERK1/2,IL-6,SIRT1).
来自暴露于HG的微质细胞的条件介质被用于评估SH-SY5Y细胞的神经毒性,有或没有MO/RA治疗.

主要成果:

高葡萄糖诱导了微质中的炎症性表型,其特征是增加CD11b,NF-κB激活,iNOS,ERK1/2酸化和IL-6表达,同时降低SIRT1水平.
在MO前期治疗中,可以逆转这些由HG引起的变化,并恢复SIRT1水平.
MO通过抵消来自HG暴露微质的条件介质的神经毒性来证明神经保护活性.
罗斯马林酸 (RA) 显示出与MO.MO.相似的疗效.

结论:

梅丽莎官员植物 (MO) 和其组成部分迷酸 (RA) 有效地减轻高血糖引起的神经炎症和微质中的氧化失衡.
MO和RA抑制了亲炎性微质表型和下游信号通路 (ERK1/2-NF-κB-iNOS).
莫表现出神经保护性质,表明其在管理糖尿病相关的神经并发症方面的潜力.

关键词:

梅丽莎·奥菲西纳利斯L.L.糖尿病糖尿病患者糖尿病患者微质细胞中的微质细胞神经炎症是一种神经炎症.罗斯马林酸是一种酸.

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