泰国人的大脑参数与正常认知,轻度认知障碍和痴呆症的比较
Pariwat Wisetwongsa1, Sitha Piyaselakul1, Yudthaphon Vichianin2
1Department of Anatomy, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Brain sciences
|February 26, 2025
概括
大脑体积和皮质厚度的减少与认知能力下降相关. 左桃体/内体积比率显示为早期发现神经认知障碍 (NCD) 的生物标志物具有前途.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 神经认知障碍 (NCD) 包括轻度认知障碍 (MCI) 和痴呆等疾病.
- 了解结构性大脑变化对于诊断和管理NCD至关重要.
研究的目的:
- 为了研究正常认知 (NC) 和NCD组之间大脑体积和皮质厚度的差异.
- 确定特定的大脑参数,可以帮助NCDs的临床决策.
主要方法:
- 使用FreeSurfer分析了116名参与者的结构磁共振成像 (MRI) 扫描 (痴呆症,MCI,NC组).
- 测量了绝对大脑体积,内体积 (ICV) - - 正常化体积和皮层厚度.
主要成果:
- 与MCI和NC组相比,患有痴呆症的个体显示大脑体积和皮质厚度显著减少.
- 左桃体/ICV比率有效地诊断了早期非传染性疾病 (83.82%的准确率) 和MCI (88.46%的准确率).
结论:
- 减少大脑体积和皮质厚度与认知能力下降有关.
- 由MRI数据和FreeSurfer分析得出的左桃体/ICV比率显示,它有可能成为NCD风险的早期生物标志物.
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