揭开痛苦中的真相:真实和欺骗性疼痛之间的神经和行为区别
Vanessa Zanelli1, Fausta Lui1, Claudia Casadio1
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Brain sciences
|February 26, 2025
概括
研究人员在观察真实与虚假的疼痛表达时发现了不同的大脑活动模式. 前前环皮质 (pACC) 对真实疼痛的反应更强,而中环皮质 (aMCC) 与感知疼痛强度相关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 疼痛研究 疼痛研究
背景情况:
- 疼痛的面部表情可以是真实的,假的或被压抑的,假的表情经常表现出夸张的或与疼痛无关的行为.
- 尽管可以观察到差异,但对个体来说,准确地检测疼痛表达中的欺骗仍然是一个挑战.
- 处理真实,伪造和压抑的疼痛表达的基础的神经机制尚不清楚.
研究的目的:
- 调查神经关联区分真实的,假的和压抑的疼痛面部表情.
- 利用隐含的情绪处理任务来检查疼痛表达观察期间的大脑反应.
- 探索大脑活动如何与疼痛和表达强度的间接评分有关.
主要方法:
- 功能性磁共振成像 (fMRI) 用于24名健康的女性参与者.
- 参与者在观看真实,假,压抑疼痛和中性面部表情的视频片段时执行了隐含的性别歧视任务.
- 扫描后,参与者为每个刺激提供了表达强度 (IE) 和疼痛强度 (IP) 的间接评分.
主要成果:
- 在所有表达类别中发现IE和IP评级的显著差异.
- 在观察真实疼痛时,与假疼痛相比,在前阴前环状皮质 (pACC) 中观察到更大的血氧水平依赖 (BOLD) 反应.
- 中皮层 (aMCC) 的大脑活动与间接疼痛强度 (IP) 评级呈现出正相关性.
结论:
- 间接评分表明参与者可以区分真正的疼痛 (更高的IP) 和假疼痛 (更高的IE).
- 对于区分真实的疼痛表达和欺骗性的疼痛表达来说,pACC似乎至关重要.
- aMCC参与编码基于面部表情感知到的疼痛强度.
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