在德国精神分裂症患者中不接受医疗建议:一个多中心跨部门研究
Karel Kostev1,2, Ira Rodemer1, André Hajek3
1Epidemiology, IQVIA, 60549 Frankfurt, Germany.
Brain sciences
|February 26, 2025
概括
违背医疗建议 (DAMA) 的出院在德国精神分裂症患者中很常见,特别是年轻人和那些有物质使用障碍的人. 了解这些风险因素对于改善患者护理和降低DAMA率至关重要.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 医疗保健服务研究 医疗服务研究
- 药物经济学 药物经济学
背景情况:
- 违背医疗建议 (DAMA) 的出院在治疗精神分裂症方面是一个重大挑战.
- 在精神分裂症患者中确定DAMA的患病率和风险因素对于有针对性的干预措施至关重要.
研究的目的:
- 确定德国住院精神分裂症患者中DAMA的患病率.
- 确定与该人口中DAMA风险增加相关的人口和临床因素.
主要方法:
- 这是一项利用IQVIA医院数据库 (2019-2023) 的多中心,横截面研究.
- 包括被诊断为初级或二级精神分裂症的住院病例.
- 多变量后勤回归分析以确定DAMA的预测因素,并根据相关的共变量进行调整.
主要成果:
- 该研究包括7663例住院治疗;DAMA率为初级精神分裂症诊断的31.1%和二级精神分裂症诊断的6.0%.
- 年龄较小的年龄组 (18-50岁),精神分裂症作为主要诊断,以及与酒精或大麻相关的同时出现的疾病与较高的DAMA风险有显著的关联.
- 调整后的赔率比率表明,这些因素对DAMA风险的大幅增加.
结论:
- 住院的精神分裂症患者表现出DAMA的高患病率.
- 年龄较小,初级精神分裂症诊断和物质使用障碍 (酒精,大麻) 是DAMA的关键风险因素.
- 建议进行进一步的研究,以探索这种患者群体中DAMA的潜在原因.
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