差异化甲状腺癌的长期结果和儿童和青少年患者的风险分层:一项44年的回顾性研究
Marko Buta1,2, Nada Santrac1,2, Merima Goran1,2
1School of Medicine, University of Belgrade, Dr Subotica 8, 11 000 Belgrade, Serbia.
Diagnostics (Basel, Switzerland)
|February 26, 2025
概括
儿童差异化甲状腺癌 (DTC) 的风险分层确定了关键的预后因素. 患有DTC的低风险患者可能会从不那么激烈的治疗中受益,改善结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 癌症研究 癌症研究
背景情况:
- 在儿科患者中差异化甲状腺癌 (DTC) 是罕见但显著的.
- 儿科DTC通常在晚期呈现,但具有有利的长期结果.
- 目前的管理目标是优化治疗和后续战略.
研究的目的:
- 在21岁及以下的患者中确定DTC的预后因素.
- 为儿科DTC开发一个风险分层模型.
- 为了确定适合较少激进治疗方法的低风险患者.
主要方法:
- 99名患有DTC的患者 (儿童和青少年) 的回顾性队列研究.
- 从1980年到2024年收集的数据.
- 多变量回归分析以确定不良事件和无事件区间 (EFI) 的独立预测因素.
主要成果:
- 儿童和青少年之间的长期结果没有显著差异.
- 超过10.5个阳性淋巴结和甲状腺外瘤扩张是不良事件和减少EFI的独立预测因素.
- 风险分为低,中,高风险的风险分层显示了EFI的显著差异,没有低风险的患者经历疾病复发.
结论:
- 细致的风险分层对于预测儿科患者的DTC结果至关重要.
- 鉴定的预后因素可以指导个性化治疗策略.
- 区分低风险的DTC患者可能允许不那么激进的治疗,而高风险的患者需要加强管理.
相关概念视频
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Cancer Survival Analysis
320
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
320


