早期视网膜变化和OCT参数的定量分析在患有或没有视网膜病的糖尿病患者中
Sulaiman Aldakhil1, Naveen Challa1, Saja A Alhoshan2,3
1Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraidah 51452, Saudi Arabia.
Diagnostics (Basel, Switzerland)
|February 26, 2025
概括
光学连贯断层扫描血管造影 (OCTA) 在2型糖尿病患者中显示出显著的微血管变化,甚至在糖尿病视网膜病变 (DR) 明显之前. 这些OCTA发现可以预测未来的视力损失.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 2型糖尿病 (DM) 是导致视力障碍的主要原因.
- 早期发现微血管变化对于预防糖尿病视网膜病变 (DR) 进展至关重要.
- 光学连贯断层扫描血管学 (OCTA) 提供了视网膜微血管结构的高分辨率成像.
研究的目的:
- 评估沙特成年2型糖尿病患者OCTA参数的变化.
- 为了比较正常个体和有或没有DR的DM患者之间的OCTA发现.
- 为了识别可能在可检测的DR损伤之前的OCTA生物标志物.
主要方法:
- 涉及4组的前性横截面研究:对照组和不同DR阶段的DM患者.
- 使用扫描源OCT (DRI Triton) 的OCTA成像.
- 分析表面毛细管 (SCP) 血管密度 (VD),状无血管区 (FAZ) 区域,黄斑厚度 (MT),状细胞层 (GCL) 厚度和视网膜神经纤维层 (RNFL) 厚度.
主要成果:
- 在DM患者中减少SCP VD,随着DR严重程度的增加,进一步减少.
- 扩大的FAZ区域与增加的DR严重程度相关.
- 鼻子象限中减少RNFL和GCL厚度,与DR严重程度相关.
- SCP VD与DM持续时间和对比度敏感性有负相关性.
结论:
- 在对照组和DM患者之间,OCTA参数有显著的差异,无论是有DR还是没有DR.
- 通过OCTA检测到的微血管和对比度灵敏度变化可能表明DR之前的早期损伤.
- OCTA显示了糖尿病眼病早期检测和监测的潜力.
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