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中性粒细胞变异对COVID-19并发症的临床影响

Khadija El Azhary¹, Bouchra Ghazi^2,3, Fadila Kouhen^4,5

¹Laboratory of Immunogenetics and Human Pathologies, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20250, Morocco.

Diagnostics (Basel, Switzerland)

|February 26, 2025

概括

住院5日多核中性粒细胞 (PNN) 水平升高预测COVID-19严重并发症,包括急性呼吸困扰综合征和死亡率. 这一发现有助于早期识别和改善患者管理.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
关键护理医学关键护理医学

背景情况:

COVID-19仍然是一个重要的全球公共卫生问题.
早期识别关键的COVID-19病例对于及时干预至关重要.
作为COVID-19严重程度的预测指标的中性粒细胞水平需要进一步调查.

研究的目的:

调查中性粒细胞水平对COVID-19并发症的预测价值.
评估中性粒细胞数量与疾病进展之间的关联.
为了确定中性粒细胞水平是否可以预测输管,ARDS和COVID-19患者的死亡率.

主要方法:

在谢赫哈利法国际大学医院对COVID-19患者的回顾性研究.
分析实验室结果 (中性粒细胞,PCT,CRP,IL-6) 和临床数据.
在入院和第5天评估中性粒细胞数量以获得预测准确度.

主要成果:

增加的多核中性粒细胞 (PNN) 水平与呼吸系统恶化和输管相关.
与初始标志物相比,5日PNN水平是输管,ARDS和死亡率的优越预测指标.
在第五天PNN水平>7.7 (10^9/L) 独立预测死亡率和ARDS.

结论:

中性嗜好症,特别是在第5天PNN升高,是COVID-19并发症的优秀预测因素.
中性粒细胞计数可以提高住院COVID-19患者的管理和风险分层.
这种标志物有助于识别患有严重结局和死亡风险较高的患者.

关键词:

这就是SARS-CoV-2病毒.这是一个复杂的并发症.死亡率死亡率作为一个中性恋者.患有COVID-19的患者.预测预测预测预测

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