大脑形态测量和认知特征在刺激性肠综合征的预测中
Arvid Lundervold1,2, Ben René Bjørsvik2, Julie Billing3
1Department of Biomedicine, University of Bergen, 5020 Bergen, Norway.
Diagnostics (Basel, Switzerland)
|February 26, 2025
概括
结合脑部成像和认知测试,可以更好地识别刺激性肠综合征 (IBS) 患者. 这种方法突出了皮下大脑结构和认知功能,这对于理解这种肠-大脑疾病至关重要.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 刺激性肠综合征 (IBS) 是一种复杂的肠-大脑疾病,涉及腹痛,肠道习惯改变和心理困扰.
- 大脑结构,认知功能和IBS临床表现之间的相互作用需要进一步阐明.
- 了解大脑与肠道之间的相互作用是解开IBS病理生理学的关键.
研究的目的:
- 在IBS患者中复制单变形态测量结果,并比较不同的软件版本.
- 评估大脑形态测量和认知表现的多变量分析是否可以将IBS患者与健康对照者区分开来.
- 确定关键的结构和认知特征,以区分IBS患者和HC患者.
主要方法:
- 结构性大脑磁共振图像 (MRI) 和可重复电池用于评估神经心理状态 (RBANS) 来自49名IBS患者和29名HC患者.
- 使用FreeSurfer软件 (v6.0.1和v7.4.1) 分析了大脑形状.
- 用单变量,多变量和具有交叉验证的机器学习技术来分析数据.
主要成果:
- 在FreeSurfer版本之间观察到形态测量的显著差异.
- 仅仅通过形态测量,就能在IBS患者和HC患者之间进行区分的能力有限.
- 将形态测量和认知测量相结合,在识别IBS患者时实现了93%的灵敏度和22%的特异性,其中皮下结构 (海马体,尾状体,皮质体) 和认知领域 (回忆,口头技能) 是关键的区分因素.
结论:
- 结合大脑形态测量和认知评估的多模式方法为IBS提供了比单独的形态测量更好的区别.
- 皮下结构和特定认知功能的确定的重要性强调了IBS中复杂的脑肠轴.
- 这些发现提倡在IBS研究中使用全面的开源框架和严格的方法.
相关概念视频
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
108
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
108
01:17Irritable Bowel Syndrome I: Introduction
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
218
01:17Chronic Bowel Disorders: Introduction
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
294
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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01:30Inflammatory Bowel Disease II: Crohn's Disease
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
157